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Mitochondrial dysfunction has been linked to numerous diseases including RA, periodontitis, neurodegenerative diseases, diabetes, cancer, and obesity 20,21,22,23,24

For example, prostate cancer and B-cell lymphomas promote FAO as the main source of energy production and express FAO enzymes at high levels, even under nutrient-replete conditions 10,11

Furthermore, as a cyto-protectant, melatonin helps alleviate several COVID-19 comorbidities, including T2DM, metabolic syndromes, and both ischemic as well as non-ischemic CVD 657

Hypertonicity induces activation of the TRPV1 signaling pathway in CECs, resulting in the activation of nuclear factor kappa B (NF-B) [44,45]

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