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Valproate Seizures: Myoclonus epilepsy Buccofaciolingual dyspraxia Ataxia (80%): Limbs, Gait, Speech Spastic paraparesis: Progressive Onset: Early adult Pyramidal signs Tendon reflexes: Increased Spasticity (30%) Vibration sense: Reduced or Normal Not diet responsive Weakness & Atrophy Distal legs

Structural and metabolic changes in bone

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The ROS produced, in turn, increases VEGF, monocyte chemoattractant protein- 1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) expression in microvascular endothelial cells, thus leading to leukostasis and breakdown of BRB (Ola et al., 2012)

Green tea, which is rich in antioxidants like catechins, stimulates metabolism and promotes fat-burning [12]