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Finally, salinomycin (Sal)originally identified in a high-throughput screen for CSC-targeting agents (247, 248)sensitizes renal cancer to ferroptosis by downregulating PDIA4 via autophagy, thereby suppressing the ATF4SLC7A11GPX4 axis (249, 250)

Here, the positive outcome reestablished tendon-muscle continuity will be supported by the functional, biomechanical, microscopical, and macroscopical findings as well as eNOS , iNOS , nNOS , COX-2 mRNA levels, and NO- and MDA-levels in the defect formed after dissecting quadriceps tendon from the quadriceps muscle, presenting a healing potential of its own

Todays article reveals a perfect example of this phenomenon