Regular supplements of collagen peptides offer a non-pharmacological approach to improving cardiovascular health [144]
Physiological fatigue corresponds to a homeostatic process, selected by evolution for its usefulness, whereas pathological fatigue unravels a dyshomeostatic state, which reflects a combined dysfunctioning of numerous potential systems, revealed by both physiological issues (chronic inflammation, mitochondrial dysfunctioning, cardio-pulmonary pathologies, endocrinopathies, vitamin deficiencies) and interoceptive processes, with inappropriate corrections by the brain of biological perturbations
Growth hormone, produced in the pituitary gland, does not only regulate growth
In middle-aged mice on an HFD, 8 months of UA supplementation improved spontaneous exercise and grip strength, and 6 weeks of treatment boosted running endurance in aged mice
The clinical evidence base supports its use as a tool for maintaining antioxidant status, supporting liver and immune function, and reducing oxidative burden, particularly in individuals whose endogenous production is compromised by age, chronic stress, illness, or inadequate nutrient precursor availability
