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Osteopontin (OPN) also binds to CD44 inducing cell signaling that mediates tumor progression and metastasis [23]

Mechanistic Studies in Gnotobiotic Models: Animal models where the microbiome is controlled (germ-free or colonized with defined communities) are invaluable for proving mechanistic links

doi: 10.1136/ard.2011.153312 36 WangJYChenXJZhangLPanYYGuZXHeSMet al

In the Central Nervous System GH and IGF-1 both contribute to neural development, nerve myelination, amyloid clearance so important in the development of Alzheimers disease and anti-inflammatory mechanisms within the central nervous system

Exon 4-skipping GLT-1: a new form of an abundantly expressed glutamate transporter