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Therefore, adequate folate intake before and during pregnancy (especially during early pregnancy when the neural tube is still forming) helps prevent neural tube defects in the brain and spinal cord

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Activated LRRK2 then increases intracellular iron content by enhancing Fe 2+ uptake, which in turn induces ROS generation and pro-apoptotic molecule expression

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Ultimately, this review will highlight how exercise-enhanced DNA repair serves as a crucial therapeutic avenue for mitigating sarcopenia, identifying critical knowledge gaps, and charting promising future research directions to advance the field towards more effective interventions for healthy muscle aging