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for instance, certain vitamin B-dependent epilepsies necessitate doses up to 100-600 mg per day to control seizures, with long-term supplementation of about 30 mg daily for life to prevent symptom recurrence

At present, natalizumab, a humanized monoclonal antibody against the cell adhesion molecule 4-integrin, is advantageously used in the treatment of multiple sclerosis and Crohn's disease (24)