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Targetable pathways for alleviating mitochondrial dysfunction in neurodegeneration of metabolic and non-metabolic diseases

doi: 10.1016/j.rbmo.2022.05.010 58 AgarwalAPanner SelvamMKArafaMOkadaHHomaSKilleenAet al

This work was supported by the NIH (grants R01 EB026332 and R01 EB026285 (to M.B.), R01 DK131005 (to A.J.O.), R01 AI148623 and R01 AI143757 (to A.S.B.) and RM GM135102 and R01 AI147023 (to K.C.H.)) and National Science Foundation (grant EF-2125383 (to K.C.H.))

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Protein ADP-ribosylation is a post-translational modification where ADP-ribose from NAD + is transferred to protein substrates by ADP-ribosyltransferase enzymes, such as poly ADP-ribose polymerase (PARP)