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Intrinsic factor (IF), a protein secreted in the stomach, joins B12 and safely transports it past the protein-digesting enzymes that would otherwise destroy the vitamin

1 This observation suggests that use of a low serum vitamin B 12 level as the sole means of diagnosis may miss up to one half of patients with actual tissue B 12 deficiency

Cardiorespiratory polygraphy additionally collects data on breathing, cardiac activity and oxygen levels