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10.3389/fnins.2021.673440 Front

The current study demonstrates that microglial activation and consequent neuroinflammation remain primary initiators and participants in the onset and progression of neurodegenerative diseases [183]

Additionally, inhibiting STEAP family member 1 (STEAP1) in a sepsis-induced ALI model reduced inflammatory responses and ROS generation, increased NRF2 and GSH levels by activating the SLC7A11/GPX4 axis, and suppressed ferroptosis, thereby protecting pulmonary endothelium [75]

Yamaguti, K

Accordingly, those treated with cyclophosphamide face increased risks of POI and infertility, potentially arising from the toxic effects of its metabolites acrolein and phosphoramide mustard