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The intrinsic pathway involves mitochondrial permeability transition pore (MPTP) opening, controlled by BCL-2 family proteins (e.g., BAX/BAK)

That means oxygen delivery drops

This dual alteration attenuates mTOR activity, which in turn inhibits downstream protein synthesis mediated by eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70S6K)