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The peptide also has some anticoagulating properties on its own: It binds to platelets in the blood, enabling action at the clotting site. Without an added bonding agent, heparin applies its anti-clotting properties indiscriminately, not just at blood clot sites, and clears quickly, its half-life only 60 to 90 minutes

doi:10.1016/j.neuro.2010.11.008

All of the participants had recurrent or metastatic breast cancer that was progressing despite two or more chemotherapy regimens directed specifically at HER2