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As discussed before in this manuscript, BBB breakdown is considered to be the basic pathophysiology of HT, and BBBP is directly correlated with the appearance of subsequent HT, suggesting that the assessment of the BBB permeability should be the most promising predictor of HT (154)

CagriSema produced mean weight loss of 13.7% at 68 weeks compared to 3.4% with placebo, and 73.5% of CagriSema-treated participants achieved HbA1c of 6.5% or below compared to 15.9% with placebo