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Fatty acid desaturase 2 (FADS2) gene encodes a rate limiting enzyme in the synthesis of long chain poly unsaturated fatty acids from essential fatty acids, and FADS2 gene rs174583 single nucleotide polymorphism (SNP) has been reported to be a risk factor in cardiovascular events by affecting hyperglyceridemia, hyperglycemia and hyperinsulinemia

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Presently, recommended dietary therapies for adult-onset type II citrin deficiency are mostly main chain triacylglycerol (MCT) oils (5 mL twice daily), Sodium pyruvate (0.10.3 g/kg/day), low carbohydrates and high protein supplements [132, 133, 140, 142]