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Following treatment-induced stress or destruction, tumor cells release DAMPs such as calreticulin (CRT), 33 high mobility group box 1 (HMGB1), 34 and adenosine triphosphate (ATP), 35 which are recognized by APCs, especially dendritic cells (DCs), via PRRs, 36 leading to antigen uptake, maturation, and cross-presentation to T cells

GST enzymes are essential in detoxifying endogenous or exogenous toxic compounds by catalyzing the conjugation of the nucleophilic thiol group from reduced GSH to co-substrates possessing an electrophilic center

Proton pumps are also important in the transport of various substances in the body, as we will see in detail in later sections

This process ultimately results in diminished melanin deposition within the body and contributes to the slowing of skin aging

Blood 124(21):534, 2014