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The mechanism of GPX3 function in different types of cancers is shown in Fig

Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig

References lesak, I., lesak, H

For interaction, the chloroethyl moiety cyclizes to form the highly reactive aziridinium ion intermediate that reacts readily with electron-rich sites, as shown with N7-guanine in Figure 3