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Gene-Associated Pathways were identified using the Enrichment_rank of the pathways based on their statistical significance ( P values) of KEGG pathway enrichment analyses for AD-associated genes from different sources: Enrichment_rank_1 used AD-associated genes from Open Targets, and Enrichment_rank_2 used genetically associated AD genes identified in genome-wide association and familial studies

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183,277 Active caspase-1 then catalyzes the proteolytic cleavage and maturation of proIL-1 into the biologically active IL-1, which leads to acute flares of gouty arthritis