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Description

HNE at physiological concentrations (3 M) blocked nigericin and ATP-induced cell death, as well as secretion of IL-1, by mouse primary macrophages and human peripheral blood mononuclear cells

This cascade promoted M1 microglial polarization and the expression of inflammatory cytokines

Figura, M

M.SantosT.et al (2022)

ChIP Analysis Results The ChIP experiment results confirmed that STAT3 directly binds to a specific region (P2) of the GPX4 promoter, but not to other predicted binding sites (P1, P3, and P4)