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Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis

10.1016/S0169-328X(97)00343-4 261

To assess the functional importance of glycolysis on RG differentiation, we silenced the expression of Pfkfb3, a hypoxiainducible activator of the ratelimiting glycolytic enzyme phosphofructokinase1 (Pfk1)

Murphy DA, Courtneidge SA

Gut-Derived Burden Endotoxin and microbial metabolites travel from the intestine to the liver through the portal circulation and may increase inflammatory and metabolic workload