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For example, a DNA repair protein, redox factor Ref-1, was reported to promote the DNA-binding activities of several transcription factors, including HIF-1 and p53, which confers cytoprotective function under hypoxia

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Unlike SIRT5, low expression of SIRT3 leads to increased acetylation and phosphorylation of PDHE1, reduced PDHase activity, and enhanced glycolysis [53]

ICP should be monitored, maintaining it between 20 and 25 mmHg, with a brain perfusion pressure above 50 mmHg.99 When ICP is above 25 mmHg, boluses of hypertonic saline solution or intravenous mannitol at 20% should be added to the treatment.100 29 The presence of HE in a patient with ACLF confers a poor prognosis, increasing the risk for mortality in both the short and long terms

Statements Author contributions TK: Writing review & editing, Writing original draft