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In line with CPIC/DPWG guidance, when citalopram or escitalopram are nonetheless prescribed, therapy should begin at approximately 50% of the standard starting dose (e.g., escitalopram 5 mg/day instead of 10 mg/day), followed by slow titration with careful monitoring for adverse effects such as gastrointestinal intolerance, sedation, and QTc prolongation ( Scenario 2 CYP2D6 ultrarapid metabolizer with HTR2A rs7997012 CC genotype: A second example involves a patient classified as a CYP2D6 ultrarapid metabolizer (UM) due to gene duplication or increased-function alleles, combined with the HTR2A rs7997012 CC genotype (Nahid and Johnson, 2022)

On the other hand, increased intracellular calcium level via glutamate receptors can lead to generation of more free radicals and subsequently a rise in lipid peroxidation

This question usually comes from the belief that changes in melanin activity could affect how skin reacts to UV exposure

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Benkler, C