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The studies in cancer cells on the effect of vitamin C in regulating p16 INK4a and p21 expression seem at odds with the observation in ESCs, iPSCs and tissue specific stem cell cultures in which vitamin C treatment silences the p16 I NK 4 a /p19 A RF locus and is associated with reduced expression of p53 and p21 (He et al., 2008

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This Review details the current understanding of the pathogenetic events in Lyme arthritis, from initial infection in the skin, through infection of the joints, to post-infectious chronic inflammatory arthritis

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