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In addition, the supplementation of selenium, alone or together with vitamin E, did not show any benefits regarding the risk of prostate, lung, or colorectal cancers after 5.5 years of follow-up (86, 87)

Most mutations (including the p.Gly376Asp) promote cytoplasmic mislocalization [20] and formation of toxic protein aggregates [21], coupled to a depletion TDP-43 in the nucleus that causes a loss of the nuclear function of the protein [22]

370 This evidence highlights the critical role of neutrophils in the pathogenesis of SLE

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In the human knee joint, the selenium concentration in cartilage is approximately 80 g/kg dry weight, whereas the selenium concentrations in ligament and meniscus are 270 and 307 g/kg dry weight, respectively 60,61