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4-hydroxy-2-nonenal (4-HNE) is a signaling molecule that stimulates gene expression and cell survival at physiological levels

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No adverse effects were reported, but rigorous, large-scale trials are lacking

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Document dosing rationales (route, concentration, frequency) and use pilot results to set dose escalation or fixeddose arms in the main study

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10.1152/ajplung.00159.2014 42

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Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, Liu Y, Yang Z, Dong R, Xue H, Wang L

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