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Similarly, dim light during the dark phase accelerated tumor onset and growth in tamoxifen-treated breast cancer xenografts, alongside reduced melatonin levels 162

For the survival experiments, animals were maintained until manifestation of neurological signs

This indicates that an inflammatory environment has been induced in which the levels of potentially pathogenic cytokines are likely to cause, or contribute to the induction of neuronal damage or death ( It is now clear that there are also major changes in the immune system associated with some central disorders, of which Huntington's disease represents a good example