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All authors contributed to the article and approved the submitted version Acknowledgments The authors thank Servio de Imuno-Hemoterapia from Instituto Portugus de Oncologia de Lisboa Francisco Gentil (IPOLFG EPE) for providing the buffy coats from healthy donors

TLR pathway activation leads to secretion of pro-inflammatory cytokines, like interleukin (IL)-1, IL-6, and tumor necrosis factor-, as well as type 1 interferon