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3-Nitrotyrosine (Tyr-NO 2 ) Tyr-NO 2 is a stable marker of oxidative and nitrosative stress in inflammatory disorders

Neuropsychobiology 79, 8999

The most significant marker, considered a gold standard, was F2-isoprostane and this was significantly more reduced by oral Acetylglutathione than with the IV glutathione.[11],[12] Oral S-Acetyl Glutathione, dosed 200mg daily for 7 days, AM IV 1400mg, single dose Serum and urine tested after 1 week of administration N=6, (4 female, 2 male, average age 45) Markers chosen are measures of Antioxidants F2-Isoprostane is the Gold Standard of oxidative stress markers Conclusion: Oral S-A GSH compares favourably to a one-time, equivalent dose of IV administered Glutathione GSH : Blood levels are lower in the A-GSH group as compared to the IV group because the A-GSH is being taken up by the cell.[13] This is substantiated by the following markers: F2-Iso : (F2- isoprostane ) measurement of redox status and oxidative stress

50 Spontaneous intramolecular rearrangement and elimination of the carbamate group at C10 of mitomycin C results in a second alkylation reaction with the opposite strand of DNA to induce cytotoxic 1,2-GG interstrand crosslink lesions (Figure 7)

Glutathione supports detoxification and redox balance