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Electrophilic products of lipid peroxidation formed in the presence of ROS (e.g., Isolevuglandins (IsoLGs)) promote the activation of NETosis, which play a direct role in immune activation in hypertension [193]

Radiotherapy-induced lung fibrosis is a fibrotic disease resembling idiopathic pulmonary fibrosis and is one of the most common side effects of thoracic RT

Moreover, the above 7 metabolites were mainly belonged to lipids and lipid-like molecules, followed by nucleosides, nucleotides, and analogues

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The cytosolic NADP redox state is typically considered to be highly reduced, with NADPH/NADP + ratios of 50100:1 being standard textbook values [50, 51]