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The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance

The activity of dihydroorotate dehydrogenase (DHODH), an enzyme that couples de novo pyrimidine synthesis to the mitochondrial electron transport chain, is often compromised, resulting in altered pyrimidine pools and increased reliance on salvage pathways to sustain DNA and RNA synthesis during proliferation [248,249,250,251]

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Mechanistically, Rd targets GPR30 to phosphorylate AMPK via the PKA-LKB1-AMPK kinase cascade

Before treatment, cases appeared with severe and moderately severe states of paralysis, with a maximum House-Brackmann score of 5 and minimum score of 3