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Disclosures: YunLing Xue: Nothing to Disclose, Xiaoqing Liu: Nothing to Disclose, Peng Hu: Nothing to Disclose 472 HISTOLOGICAL IMPROVEMENT OF FIBROSIS IN PATIENTS WITH HEPATITIS C WHO EXHIBIT FOR 5 YEARS A SUSTAINED VIROLOGICAL RESPONSE TO ANTIVIRAL TREATMENT WITH DIRECT-ACTING ANTIVIRALS Takayuki Iwamoto 1 Yasutoshi Nozaki 1 Yoshiki Ito 1 Yuki Tahata 2 Hayato Hikita 2 Tetsuo Takehara 2 Hideki Hagiwara 1 , 1 Kansai Rosai Hospital, 2 Osaka University Background: The histological improvement of liver fibrosis in patients with hepatitis C who achieved sustained virological response (SVR) to direct-acting antiviral treatment (DAA) has not been investigated comprehensively

Their multifaceted actions on redox signaling, inflammation, and apoptosis highlight their potential as supportive therapeutics in preventing and managing metabolic and degenerative diseases

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286,287 It is a condition distinct from atherosclerosis and common in diabetes, chronic kidney disease, and aging, and involves lactylation