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The starting conformations were obtained by manually binding GS(H) to a snapshot of the MD simulation of TRaQ-G and the crystal structure of MeTRaQ-G, respectively

To the best of our knowledge, this was the first study of a potential therapy targeting the glycocalyx in sepsis to demonstrate that it can be restored by an exogenous substance (138)

The SLD decreased after chemotherapy (14.3 cm at baseline 12.1 cm on Day 11), increased during treatment delay (reaching a peak of 21.3 cm on Day 74), and decreased again after treatment re-initiation (17.6 cm on Day 84)

Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage