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Concurrent administration of pyridoxine with these medications has been reported to lower their therapeutic levels, so monitoring and dosage adjustments of the anticonvulsant might be required if high-dose vitamin B is given

Affected mice were also found to have increased intestinal permeability, sometimes referred to as leaky gut, which was measured by what occurs when inflammation, which interferes with the normal tight junction of the intestinal epithelium, allows large molecules to cross into the bloodstream

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Negative effects of a high-fat diet on intestinal permeability: A review (in Eng)

This article covers the exact dosing protocol, the biological rationale behind the 46 hour offset, and the three timing mistakes that negate the synergy entirely