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In response to the concerns noted above that reduce the sensitivity and specificity of serum B12 and confound the diagnosis of B12 deficiency, many investigators now recommend measuring one functional B12 biomarker (serum methylmalonic acid or serum homocysteine) if serum B12 concentrations appear inadequate to ensure a more accurate assessment of B12 status

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Many experts consider vitamin B12 injections the safest and most effective option