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If supplements or fortified foods arent used, injections can restore levels

Antioxidants: Mushrooms contain antioxidants like ergothioneine and glutathione, which help protect cells from damage caused by free radicals

[68] found that peripheral nerves with enforced elevated levels of SAMe, were specially characterized by DNA hypermethylation at promoter and enhancer regions of several lipid synthesis genes, which contributed to the peripheral myelin defects