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By contrast, vitamin B12 has prescription dosing schedules for deficiency

Warning signs include persistent fatigue despite adequate sleep, cold intolerance (especially cold hands and feet), menstrual irregularity or cessation in female subjects, hair thinning or shedding, and mood disturbances (irritability, low motivation)

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A meta-analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease