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The World Anti-Doping Agency (WADA) includes it under the category of S0 Non-approved Substances, which covers any pharmacological agent that has not been approved for human use by a regulatory authority

However, it did not provide comprehensive insights into the pharmacokinetics and effects on vitamin B12 and related biomarkers after repeated intranasal administration

Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system

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KPV (Lys-Pro-Val) shows anti-inflammatory effects in IBD models but lacks hemorrhoid-specific research