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Activation of Akt/Wnt/-catenin signal transduction by CXXL12/CXCR4 induces the expression of VE-cadherin and stabilizes its interaction with VE-cadherin-associated phosphatases to maintain the integrity of endothelial cells and favours a contractile phenotype over a synthetic phenotype in arterial SMCs, thus inhibiting atherosclerosis

doi: 10.1523/JNEUROSCI.0037-06.2006 221 WangC.XiongM.GratuzeM.BaoX.ShiY.AndheyP

Please store medicinal and/or dietary supplements out of reach of small children

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In certain embodiments, the dose is between 0.001 mg/kg patient weight to about 15 mg/kg per kg patient weight per administration, or 0.01 mg/kg to about 1.5 mg/kg