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Over time, the hyaluronic acid in synovial fluid breaks down, contributing to joint pain and stiffness in people with osteoarthritis

GPA attenuates IL-1 induced ferroptosis by reducing the levels of MDA, intracellular iron, and ROS, while simultaneously upregulating the expression of GSH, GPX4, and ferritin

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Calf muscles (soleus, plantaris, and gastrocnemius muscles of lower hind-limb) were collected from male C57BL/6J mice (8-weeks old) of four experimental groups ( n =3/group): control, 5 days of muscle-disuse induced by tail suspension, and 3 days pre-administration of GSSSG or LASSS (about 50 g/g body weight per day in drinking water) followed by 5-days muscle disuse without the GSSSG and LASSS supplementation

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