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This stress can cause a decrease in the production of inflammatory cytokines like TNF- and interleukins (such as IL-6, IL-10, and IL-1), ultimately leading to the death of these cells

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We speculate that neuronal death in Alzheimers disease is essentially not degenerative but ischemic in nature, being caused synergically by the excessive intake of -6 PUFA-rich vegetable oils for oxidizing Hsp70.1 and long-standing brain ischemia due to age-dependent arteriosclerosis or A deposition in the capillary wall to facilitate -calpain activation