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Human Data: While animal studies (mostly in rats) are overwhelmingly positive, large-scale, peer-reviewed human clinical trials are still limited

doi: 10.1038/ncomms11190 [DOI] [PMC free article] [PubMed] [Google Scholar] 95.Fuhrmann-Stroissnigg H, Ling YY, Zhao J, et al

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Although these studies primarily focus on safety and tolerability, they also provide the first human data on pharmacokinetics and, early pharmacodynamic (biomarker)effects