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TMZ is an FDA-approved DNA alkylating agent, and when combined with RT, it has shown to increase OS in patients with GBM

Ehrmann, F

Nature 395: 189194 Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, Deresinski SC, Herzenberg LA (1997) Glutathione deficiency is associated with impaired survival in HIV disease