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A liver x receptor (LXR) acts as a cholesterol sensor, working in a similar way to sterol response element binding proteins (SREBPs), lowering cholesterol levels by increasing RNA expression of target genes associated with reverse cholesterol transport, bile acid synthesis, and intestinal cholesterol absorption (Piccinin et al., 2021)

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current studies have focused primarily on wild-type p53, while the impact of hotspot p53 mutations (e.g., R175H and R273H) on ferroptosis susceptibility, and whether mutant p53 retains or rewires the dual regulatory function, is unknown

The different arginine methylation modifications of CRIP1 enable it to play distinct functional roles in the recurrence process of SCLC, synergistically promoting SCLC recurrence after chemotherapy