The primary long-term risk is tolerance development from inadequate washout periods between cycles receptor desensitization becomes progressively harder to reverse if cycles run back-to-back without 14-21 day breaks
doi: 10.1080/17461391.2021.2001575
10.1126/science.1101738 32 DavidsonW
Lynn|Grimes, David A.|Sutherland, Laura|Mendis, Tilak|Reyes, Lydia|Greene, Paul|Ford, Blair|Moskowitz, Carol|Fahn, Stanley|Jacques, Carol|Friedman, Joseph H.|Lannon, Margaret|Saint-Hilaire, Marie H.|Ellias, Samuel|Thomas, Cathi-Ann|Clark, Jeffrey|Manyam, Bala|Simpson, Patricia|Wulbrecht, Brian|Whetteckey, Jacqueline|Comella, Cynthia L.|Goetz, Christopher|Blasucci, Lucia M.|Tanner, Caroline|Tetrud, James|Togasaki, Daniel M.|Stewart, Tracy|Lang, Anthony|Birnbaum, Alex|Miyasaki, Janis|Johnston, Lisa|So, Julie Activity enhances dopaminergic long-duration response in Parkinson disease Neurology [00283878]
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