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Nature 561 , 189194 (2018)

While lipid accumulation has multiple effects on cellular signaling, 3 major lipid-associated inhibitory phosphorylation events on the insulin signaling pathway include (a) acylglycerol-induced pIR at T1150 (human T1160) (22), (b) fatty acidinduced pIRS1 at S1097 (human S1101) (23), and (c) ER stressmediated pJNK (24)