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& Shen, Z

When deficient, it can increase the accumulation of homocysteine, which is significant in the development of cerebrovascular diseases and cognitive impairment (58)

Exposure to antiresorptive drugs was the main focus, with users categorized based on timing since last prescription

ANCOVA was used to compare mean levels of bone specific alkaline phosphatase (BAP) and tartrate-resistant acid phosphatase (TRAP 5b) in PPI users versus non-PPI users after controlling for age, sex, body mass index, timed up an go test, 25(OH)D, estimated glomerular filtration rate, parathyroid hormone, smoking, daily dairy intake, alcohol consumption, type 2 diabetes mellitus, current or past steroid exposure, and loop and thiazide diuretics