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Walsh LC, Soltanalizadeh B, Higgins RSD, Moon MR, Lee JJ, Antonoff MB

Spinal manipulation for the management of cervicogenic headache: a systematic review and meta-analysis

A portion of the NO synthesized by RBC eNOS can diffuse into surrounding tissues or be converted into nitrite under hypoxic conditions, supporting vasodilation and contributing to the regulation of blood flow in oxygen-deprived areas (LoBue et al., 2023)

The study enrolled 617 patients, average age 62, who had never been vaccinated against shingles and were taking a TNF inhibitor for rheumatoid arthritis, psoriatic arthritis, or another condition

It acts as a non-selective agonist at MC1R, MC3R, MC4R, and MC5R, with particularly high potency at MC1R, the receptor governing melanogenesis in epidermal melanocytes via the cAMP-PKA-MITF pathway