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122-126 The use of vitamin supplements has also been associated with improved pregnancy outcomes in HIV-infected pregnant women, 122,127 increased appetite in HIV-infected children, 128 and better health and survival of children with HIV

The primary challenge in treating CNS disorders is to achieve effective drug delivery to the brain parenchyma

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J Biol Chem 248(1):2532 Busiello RA, Savarese S, Lombardi A (2015) Mitochondrial uncoupling proteins and energy metabolism

Conclusion ICH, particularly spontaneous ICH caused by hypertension in the basal ganglia, remains a leading cause of disability and mortality, with complex pathological mechanisms and multistage progression complicating treatment