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Focusing on NAFLD, several studies have shown that a total energy deficit (~500 kcal/day resulting in ~1,500 kcal/day for women and ~1,800 kcal/day for men) leads to a decrease in body weight, transaminase levels, total body fat, visceral fat, and IHLC, regardless of how it is achieved [15,22,30,31]

Subgroup analysis was introduced by subdividing RCTs according to whether the peripheral neuropathy diagnosed in patients was diabetic or non-diabetic

L37 and V40 on TM1 packing against L363 and P366 on TM7)

doi: 10.3389/fcell.2022.806890 11 LongoNFrigeniMPasqualiM

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