glutathione peroxidase and vitiligo Vitiligo: interplay between oxidative stress immune system Frontiers | Immunometabolism in the

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It has been detected in central nervous system tissues, peripheral organs, and various biological fluids across multiple animal models, although its biosynthetic origin and precursor structure remain incompletely characterised

It regulates mitochondrial activity through modulation of transcription factors and is a crucial cofactor in the -oxidation of fatty acids, which facilitates the cellular energy production process (Sahebnasagh et al., 2022), balancing hypertonicity-induced imbalances between oxygenase and antioxidant enzymes, reducing ROS production, inhibiting lipid peroxidation, preventing oxidative DNA damage, and suppressing the production of heme oxygenase-1 and cyclooxygenase-2

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In order to develop effective therapeutic strategies, it is therefore essential to identify the subtype-specific molecular mechanisms underlying disease progression and resistance to chemotherapy