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For most body types with adequate subcutaneous fat, 90 degrees (straight in) is appropriate

2 Literature search strategy Two electronic databases, including PubMed and Web of Science, were searched from January 1998 to August 2024

YLL contributed to visualization during the studies and wrote the original draft of the manuscript

Chronic erlotinib treatment, as reported by Mak et al., led to hypomagnesemia, triggering substance P receptor-mediated oxidative stress and resulting in cardiac dysfunction ( 3 Clinical manifestations of EGFR-TKIs-related cardiotoxicity Since the advent of EGFR-TKI drugs, their associated cardiovascular adverse events have been extensively documented, including prolonged QT intervals, HF, atrial fibrillation (AF), myocardial infarction (MI), pericardial effusion, hypertension, and cardiac valvular lesions (Figure 2) ( FIGURE 2 3.1 QT interval prolongation Extended QT intervals pose an elevated risk for severe arrhythmias, including torsade de pointes (TdP), a potentially fatal condition precipitating sudden cardiac death ( Within the realm of EGFR-TKIs, the third-generation variant, osimertinib, exhibited substantially higher rates of QT interval prolongation compared to other EGFR-TKIs (ROR = 49.19, 99% CI: 25.8893.47), other targeted NSCLC therapies (ROR = 6.13, 99% CI: 4.438.48), and the overall VigiBase database (ROR = 14.34, 99% CI: 10.7919.04, IC025 = 3.38)

Hong Kyu Kim, Young Il Kim, Chul Hee Kim, Joong Yoel Park, Sung Kwan Hong, Jae Dam Lee, Ki Up Lee Korean Diabetes J